Among them, fibroblast growth factor-21 (FGF-21), fetuin-A, selenoprotein P (SEPP), sex hormone-binding globulin (SHBG), hepatocyte-derived fibrinogen-related protein 1, leukocyte cell-derived chemotaxin 2 (LECT2), and angiopoietin-related growth factor (AGF), are considered to be the most important hepatokines in modulating the pathogenesis of obesity. This evidence concerns the gene FGF21 and obesity due to melanocortin 4 receptor deficiency.