It could be observed that MORC1, MORC2, and MORC4 manifested a high diagnostic value for CRC, with an AUC of 0.801, 0.943, and 0.933, respectively, whereas the diagnostic accuracy of MORC3 was lower (AUC = 0.578) (Fig. 2d). Here, MORC3 is linked to colorectal carcinoma.