Notably, activated CD4+ T cell, CD56bright NK cell, effector memory CD4+ T cell, effector memory CD8+ T cell, γδT cell, immature dendritic cell, macrophage, NK cell, NK T cell, Th1 cell, Th2 cell, Th17 cell, eosinophil, mast cell and neutrophil consistently showed statistical significance in both differential and correlation analyses, suggesting a strong connection across the risk score and the quantities of immune infiltration cells in DLBCL, especially a negative correlation with the majority of anti‐tumor cells. The gene discussed is CD4; the disease is diffuse large B-cell lymphoma.