Alternatively, downregulating tumor‐derived cAMP in the TME by cAMP pharmacological inhibitors or activating the TLR8 signaling pathway by synthetic poly‐G3 and natural TLR8 ligand can prevent the induction of senescence in responder T cells while reversing the suppressive effect of senescent T cells.103, 196, 197. The gene discussed is TLR8; the disease is neoplasm.