In an immune‐competent liver cancer model, p53‐driven tumor senescence moderately declined the percentage of immune suppressors (MDSCs and neutrophils) while prominently increasing the infiltration of immune effectors (macrophages, CD4+ T cells, and CD8+ T cells), driving a shift from an immune‐incompetent to an immune‐competent TME.166. This evidence concerns the gene TP53 and neoplasm.