TNF and Alzheimer disease: Th2/Th22 cytokines are overexpressed in the acute stages of canine cutaneous atopic inflammation (Olivry et al, 2016), whereas TNFα is expressed constitutively in many inflammatory conditions, including AD (Danso et al, 2014; Hsu et al, 2018; Olivry et al, 2016; Rouaud-Tinguely et al, 2015; Smits et al, 2017).