The differentially expressed genes upregulated in Arm A as compared to Arms B and C include REL, a subunit of NFkB for which inhibition has been shown to block cancer growth in mice58 and is thus posited to be a potential myeloid checkpoint molecule; the previously discussed CCR7; and EZR, which encodes a protein that is crucial for cytoskeletal and ECM alterations and interactions that is associated with tumor-promoting TAMs.59 This evidence concerns the gene REL and cancer.