PI3Kγ is expressed in different types of neurons and has been implicated in a variety of neuronal functions, including odorant signaling,26 antinociceptive response,27 cannabidiol anticonvulsant and neuroprotective effects,28 GLP-2 signaling29; itching signal transmission,30 ADHD,31 μ-opioid receptor signaling,32 morphine analgesia33 anti-hyperalgesia,34 and NMDA-signaling.35 The gene discussed is GCG; the disease is attention deficit-hyperactivity disorder.