Expression of Angptl4 in wild-type fibroblasts was 38.8% elevated 72 h after co-culture with primary KPC mouse pancreatic cancer cells compared to the expression without co-culture with KPC cancer cells (Figure 9A), suggesting that cancer cell-driven paracrine factors may contribute to regulating Angptl4 expression. This evidence concerns the gene ANGPTL4 and pancreatic neoplasm.