,47 The tumor-promoting role of ANGPTL4 has been described in several cancer types, for instance, increase proliferation and promote metastasis in gastric48 and hepatic cell carcinoma,49 increase cell migration and invasion in colorectal cancer,50 promote tumor progression in oral cancer51 and promote pro-angiogenic factors in Kaposi-sarcoma.52 The gene discussed is ANGPTL4; the disease is colorectal cancer.