A previous single-cell RNA-sequencing (scRNA-seq) study profiled cell heterogeneity during different stages of pancreatic cancer progression across various genetically engineered mouse models, namely KIC (Ptf1a/p48-Cre; lox-stop-lox-KrasG12D/+; Ink4alox/lox), KPC, and KPfC (Pdx1-Cre; lox-stop-lox-KrasG12D/+; Trp53lox/lox).29 This evidence concerns the gene PDX1 and familial pancreatic carcinoma.