We found that LPS-stimulated active TC exosomes effectively inhibited LPS-induced caspase-3 activation and cleaved caspase-3 in ECs, but blocking the expression of miRNA-146 in LPS-stimulated active TC exosomes clearly reversed the protective effect of LPS-stimulated active TC exosomes on EC apoptosis during sepsis. The gene discussed is CASP3; the disease is Sepsis.