In a previous study from the PROCESS trial, which included patients with sepsis visiting the ED, there was no difference in 30-day survival between above and below TIMP-2 × IGFBP-7 levels (cut-off >2.0 ([ng/mL]2/1000) in the absence of functional criteria for AKI [18]. This evidence concerns the gene IGFBP7 and acute kidney injury.