REN and glomerulosclerosis: In our case, despite the patient's advanced age, massive proteinuria, and eGFR <30 ml/min/1.73 m2 on admission, the patient was successfully treated with systemic glucocorticoids and renin-angiotensin system blockade, without the need for additional therapies. One of the possible explanations for the favorable clinical evolution in our patient is that the diagnosis was made at an early stage [16], as evidenced by the renal biopsy findings, with <50% of the glomeruli showing global glomerulosclerosis and interstitial fibrosis present in only 25% of the sample.