On the other hand, however, plenty of research demonstrated that inactivated or enucleated cancer cells not only retain tumor antigens to elicit vaccination effects but also tumor-targeting endothelial adhesive capabilities through overexpressing certain adhesion molecules such as CD44 and E-cadherin [98, 167], some concerns exist about nonspecific stimulation of the immune system that may elicit an undesirable immunopathological state and whether other substances in the ‘dead cells’ produces further positive effects or side effects deserves more in-depth exploration. The gene discussed is CD44; the disease is neoplasm.