Owing to the presence of surface proteins (e.g. CD44, CD47, etc.)and various adhesion factors (e.g. integrins, selectins, cadherins, etc.), these biomimetic systems can not only send ‘don’t eat me’ signals to macrophages to prolong the blood circulation time but also specifically adhere to tumor tissues to achieve targeted delivery [33, 34]. The gene discussed is CDH17; the disease is neoplasm.