While Blvra-/- mice present a powerful method to boost NIR fluorescent protein and NIR GECI expression in vivo, BLVRA deficiency may pose potential concerns for neuroscience studies due to elevated levels of oxidative stress [35], [36] and the influence of BLVRA in insulin signaling cascades leading to implication in neurodegenerative conditions such as Alzheimer’s Disease [37], [38]. Here, BLVRA is linked to Alzheimer disease.