F8 and hemophilia A: However, maintaining these trough levels with a standard half-life factor requires every other day administration for hemophilia A and around twice a week administration for hemophilia B. Therefore, in the last decade, efforts were directed toward reducing the number of infusions, obtaining higher trough levels, fewer annual bleeding episodes, and subsequently increased protection for patients, which was achieved with the introduction of extended half-life replacement FVIII or FIX drugs [7,8].