Further, flow cytometry analysis showed that the exhaustion markers induced in LM, including CTLA-4, lymphocyte activation gene 3 protein (LAG-3), PD-1, T cell immunoglobulin domain and mucin domain protein 3 (TIM-3), and T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), were exacerbated by PLP-Tf but decreased following RNR-Tf in melanoma (Fig. 2E and Fig. S3A) and lymphoma (Fig. 2G and Fig. S4A). This evidence concerns the gene LAG3 and lymphoma.