MPO and Venous thrombosis: Activated neutrophils, monocytes, and macrophages release MPO at sites of inflammation.23 Previous study examining the relationship between plasma DNA (including MPO) and DVT biomarkers (Von Willebrand Factor (VWF)), D-dimer, and P-selectin found a unidirectional relationship between plasma DNA levels compared to other DVT biomarkers.28 In the pathogenesis of VTE, it is known that one is caused by damage to the vascular endothelium, causing the induction of tissue factor and F.VII; thus, venous thrombosis is associated with the inflammatory process.