Theoretically, when viewed from the perspective of the Virchow Triad (stasis, endothelial injury, and hypercoagulability), in this study, an increase in Soluble P-Selectin levels in malignancy patients reflects a hypercoagulable (prothrombotic) condition, and the use of chemotherapy results in endothelial injury, thereby increasing the risk of thrombosis in cancer patients.5 The results of this study prove the hypothesis that high Soluble P-Selectin levels in malignancy patients using platinum-based chemotherapy can be used as a risk factor for DVT. Here, SELP is linked to thrombophilia.