,28,64 In a French cohort including 50 patients with monoclonal gammopathy-associated C3G, treatment with anti B-cell chemotherapy was associated with significantly higher kidney responses and kidney survival rates in patients who achieved a hematologic response compared with those receiving conservative or immunosuppressive therapy, indirectly suggesting that MIg plays a pathogenic role in C3 deposition.32 This evidence concerns the gene C3 and complement 3 glomerulopathy.