NRF1 and nervous system disorder: These mediators modulate key controllers of inflammation, such as Nuclear Factor-κB (NF-kB), which, when activated, increases inflammation, and regulate the expression of Nuclear Respiratory Factor 1 (Nrf1), which plays a role in cellular defenses against oxidative [6].Consuming ω-3 PUFAs can exert protective effects on the cardiovascular, retinal, musculoskeletal, and cerebrovascular systems, and positively affect neurological disorders and conditions [7–9].