Ubiquitin E3 ligases, Fbxo32/atrogin‐1/Mafbx and Trim63/MuRF1, were increased in the diaphragm at the time of cachexia onset (D12), supporting their involvement in muscle fibre atrophy, but declined thereafter, showing significant transcriptional repression at endpoint. This evidence concerns the gene TRIM63 and Cachexia.