For example, a human VGLUT3‐pT8I mutation predisposes to substance abuse and eating disorders (Sakae et al. 2015) and is related to mis‐regulation of ACh and glutamate synergy in synaptic vesicles resulting in altered striatal acetylcholine and dopamine release (Favier et al. 2024). Here, SLC17A8 is linked to substance abuse.