IFIH1 and myositis disease: Other experimental models include the recapitulation of myositis and complicated lung symptoms by immunization with antigens targeted by myositis-specific autoantibodies, such as Jo-1, transcription intermediary factor 1γ, and melanoma differentiation-associated protein-5 [21–23], as well as the overexpression of MHC class I in muscle fibers to induce myositis [24].