CD8A and graft versus host disease: In addition, based on previous reports showing that CD8+ T cells caused the GVHD manifestations [34], we also evaluated the systemic and muscle-specific changes in immunodeficient mice transplanted with CD8+ T cell-depleted hPBMCs (hPBMCΔCD8T mice) to determine the contribution of the CD8+ T cells to the observed phenotype.