CD8A and graft versus host disease: Furthermore, not only systemic symptoms, such as body weight loss and GVHD, but also muscle symptoms, such as the serum levels of AST, CK, and genes indicating muscle damage were significantly more limited in hPBMCΔCD8T mice compared to hPBMC mice, indicating that the muscle symptoms developed in parallel with GVHD symptoms in a CD8+ T cell-dependent manner in hPBMC mice.