These results corroborate the overexpression of the three proteins in PDAC tumors and demonstrate that, although the independent overexpression of these three epigenetic modifiers can be associated with specific clinicopathological characteristics in PDAC patients, the simultaneous elevation of G9a, DNMT1, and UHRF1 levels in tumor tissues is linked to a significantly poor prognosis. Here, DNMT1 is linked to neoplasm.