TARDBP and amyotrophic lateral sclerosis: Familial ALS (fALS) patient-derived motor neurons with mutant TDP-43(M337V) from [20] significantly differentially alternatively polyadenylate the 3′ UTRs of 70 genes compared to healthy, age-matched controls (n = 5, N = 10, pair-end reads of 300 bps, read depth of ~ 10,000,000 bps) (Fig. 1I, Table S15).