Next to the established risk factors tumor grading, stage, and lymph node metastasis, the biomarkers PD-L1 CPS and the T cell subtypes Th cells and CTL as well as TIL-B and plasma cells were included in the multivariate survival analysis when significantly associated with survival in the respective univariate survival analysis. The gene discussed is CD274; the disease is metastatic malignant neoplasm in the lymph nodes.