A higher density of Th cells and CTL was present in the tumor-associated stroma (p ≤ 0.05) of patients with disease relapse and a lower PD-L1 CPS and IC (p ≤ 0.05) or lower TIL-B (p ≤ 0.05) in patients with lymph node metastases or distant metastases, respectively. The gene discussed is CD274; the disease is metastatic malignant neoplasm in the lymph nodes.