FGFR2 and cholangiocarcinoma: Fibroblast growth factor receptor (FGFR) signaling is involved in the regulation of cell proliferation, survival, migration, and differentiation and is deregulated in many cancers.201,202 FGFR2 alterations can be found in 10–15% of CCA, leading to activation of different signaling pathways.163,169,203–206 The FIGHT-202 trial, a single-arm phase II study, investigated the use of pemigatinib, an oral FGFR1-3 inhibitor in patients with advanced or metastatic CCA with or without FGFR alterations.