Based on literature, the frequency of MSI-GC varies significantly between 0–44.5%.70 MSI-GC often expresses PD-L1, which is an important predictive marker for immune checkpoint inhibitor therapy.78 Epstein Barr virus‐associated GC (EBVaGC) accounts for 2–20% of all GC70 and shows a CpG-island methylator phenotype similar to MSI-GC. The gene discussed is CD274; the disease is gastric cancer.