PVR and familial pancreatic carcinoma: For instance, in pancreatic cancer, immune response in neoantigen-specific CD8+ T cells is dysfunctional, and interference with the druggable CD155/TIGIT-axis could abolish this immune escape.511 Notably, multi-omics profiling and single-cell sequencing studies showed that extensive reshaping of the immune microenvironment is tumor-stage dependent, with different classes of immune cells affected at different stages.512,513 Hence, depending on the tumor stage, different immuno-oncological treatment strategies might be needed.