Consistently, CRC cells isolated from HCT116 and Colo205 xenografts as well as PDX1 and PDX2 from mice treated with IACS-010759 displayed similar ATP levels and increased levels of cellular lactate compared with corresponding controls (Fig. 3H–K), substantiating that CRC cells can retain adequate ATP production through increased glycolysis when OXPHOS is inhibited in vivo. The gene discussed is PDX1; the disease is colorectal carcinoma.