To explore whether the ameliorated cytokine production also contributed to the superior performance of H28E cells, we established a documented CRS model through challenging of mice with human lymphoma Raji cells modified to express HER2 (Fig. 6e).38 We found that these mice receiving treatment with H28E cells exhibited substantially alleviated body weight loss or fever when compared to those infused with conventional H28Z cells (Fig. 6f, g). Here, ERBB2 is linked to lymphoma.