While the percentage of non-classical Th1, the CM Th1 CCR6+CD161+ subset often related to pathologic inflammation, was slightly higher in RDEB patients compared to HC (9.2% vs 8.4%, respectively), the absolute counts demonstrated that their numbers were significantly increased in patients (Fig. 3c). This evidence concerns the gene KLRB1 and recessive dystrophic epidermolysis bullosa.