Volcano plot (Supplementary Fig. 4b) showed that the percentage (Fig. 3a) of effector CD4+ cells, expressing or not the terminal differentiation/senescence marker CD57, and CM Th1 CD4+ subsets were significantly increased in RDEB patients while naïve CD4+ T and Treg cells were significantly decreased. This evidence concerns the gene CD4 and recessive dystrophic epidermolysis bullosa.