Volcano plot (Supplementary Fig. 3b) revealed increased percentages of effector and central memory (CM) CD4+ (4% vs 0.1% and 19.3% vs 13%, respectively) and CD8+ (5% vs 1.6% and 8.0% vs 5.2%, respectively) T cell subsets, as well as of CD14+CD16+ intermediate monocytes in RDEB adults compared to HC (Fig. 2b). This evidence concerns the gene CD8A and recessive dystrophic epidermolysis bullosa.