TP53 and malignant colon neoplasm: Besides in HPV+ HeLa cells [20], the stimulation of p53 transactivity by full-length NR2E3 (FL) was also observed in human retinoblastoma-Y79, lung cancer-H1299, colon cancer-RKO and HCT116, and breast cancer-MCF7 cells expressing wild-type p53, suggesting a conserved mechanism for NR2E3-mediated activation of p53 across at least five types of solid tumors (Fig. 1F).