Further prolongation of the fasting duration to 24 hours triggered hypoglycemia in both whole-body and pancreatic β cell-specific but not neuronal-specific Kir6.2 KO mice (Figure 4A and Supplementary Figure S7), which may have been previously misinterpreted as a consequence of enhanced insulin sensitivity in Kir6.2 KO mice. This evidence concerns the gene INS and Hypoglycemia.