KCNJ11 and Hypoglycemia: Although it has been suggested that the absence of functional KATP channels in the autonomic nervous system—the central regulator of hypoglycemia-induced counter-regulatory mechanisms—could account for the heightened glucose levels following 2DG administration in Kir6.2 KO mice,35,48 we found that both the NestinCre/0; Kir6.2flox/flox mice and their sibling controls had comparable blood glucose levels upon 2DG administration (two-way ANOVA with Šídák’s correction, P = 0.8319, F (1, 16) = 0.04658) (Figure 3B).