We assessed expression in the ACC as it has been repeatedly shown to display plasticity in neuropathic pain models and has a critical role in the expression of pain hypersensitivity and increases in anxiety-like behavior in mouse models of neuropathic pain (Zhuo, 2008; Li et al., 2010; Koga et al., 2015); however, a broader cortical analysis of Beclin-1 expression may highlight fundamental autophagy-related mechanisms that were missed by our analysis. This evidence concerns the gene BECN1 and Anxiety.