Notably, autophagy is a key activator of inflammatory responses, and a loss of function in BECLIN-1 has been found to dysregulate immune responses, including microglia release of IL1-β, a cytokine which has consistently been implicated in mouse neuropathic pain models (Scholz and Woolf, 2007; Houtman et al., 2019; Yi et al., 2021; Xu et al., 2023). The gene discussed is BECN1; the disease is neuropathic pain.