To investigate the inhibition of melanin production by DB-14 exosome in α-MSH stimulated-B16F10 melanoma cells, the cells were simultaneously treated and cultured with α-MSH (200 nM) and DB-14 exosome (1.78 × 109, 3.55 × 109, 7.10 × 109 particles/ml), and melanin levels were measured. The gene discussed is STAMBP; the disease is melanoma.