These pathways were mainly connected with the AGE–RAGE signaling pathway in diabetic complications, pathways in cancer, lipid and atherosclerosis, colorectal cancer, fluid shear stress, atherosclerosis, prostate cancer, p53 signaling pathway, cellular senescence, FoxO signaling pathway, and PI3K–Akt signaling pathway. The gene discussed is AKT1; the disease is atherosclerosis.