TP53 and endothelial dysfunction: TP53 is a tumor suppressor gene, and the p53 protein expressed by TP53 is a critical transcriptional regulator of the cell cycle, apoptosis, and DNA repair, which can protect the function of the vascular endothelium and nerves.[42] p53 can cause the expression of inflammatory factors, damage endothelium-dependent vasodilation activity, and accelerate endothelial dysfunction, which is an essential pathological factor of ED.[43] BCL2 is an apoptosis inhibitor.