NFKB1 and cystic fibrosis: Similarly, moxifloxacin inhibits NF-κB and ERK activation, which is required for IL-8 transcription, in monocytes and bronchial epithelial cells [15, 30, 31], while levofloxacin decreases levels of aerosol MP-376-induced IL-6 and IL-8 by inhibiting NF-κB activation in human cystic fibrosis bronchial epithelial cells [13].