Although the efficacy of exogenous recombinant EGF in treating leishmaniasis has not been investigated, there is evidence of the effectiveness of other immunomodulatory and growth factors such as Autologous platelet gel (APG), granulocyte and macrophage colony-stimulating factor (GM-CSF) on cure rate of cutaneous leishmaniasis [47,48]. Here, EGF is linked to cutaneous leishmaniasis.