Indeed, we showed that JC3 and JC4 prevented photoreceptor death that occurs in response to bright light injury in an Abca4-/-Rdh8-/- mouse model of Stargardt disease, likely due to their stabilization of opsin and their ability to antagonize opsin constitutive activation under these conditions, which is known to accelerate degenerative processes in the retina [24,25]. Here, RDH8 is linked to Stargardt disease.