To further investigate the effects of CCL22 suppression on rescue from radiation pneumonitis, we conducted an experiment in which female Trail–/– mice received either anti-CCL22 or control IgG treatment every other day for 2 weeks after a single whole-thoracic x-ray irradiation dose of 20 Gy (n = 5 per treatment per group) (Figure 5A). This evidence concerns the gene CCL22 and radiation pneumonitis.