To further delineate the downstream mechanism of PDGF-CC/PDGFRα signaling in ischemic stroke, we performed vascular leakage, gene expression, and immunofluorescence analyses in mice treated with imatinib or anti–PDGF-CC neutralizing antibody (pretreatment if not stated otherwise); or in mice in which perivascular PDGFRα had been ablated (see study outline in Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI171077DS1). The gene discussed is PDGFRA; the disease is ischemic stroke.