This is supported by a line of evidence including studies showing that PDGF-CC/PDGFRα signaling is associated with fibrotic and myofibroblast expansion in other organs (23, 47–51) and that ablation of PDGFRα in myofibroblast progenitor cells reduces myofibroblast differentiation and improves liver function in a model of liver disease (49), while sustained myofibroblast expansion is detrimental to healing processes (21). This evidence concerns the gene CXCR1 and liver disorder.