ACVRL1 and breast cancer: The final signature — which included these 4 genes as well as ACVRL1 — teased out a distinct cluster of myeloid cells and TAMs when imposed on 2 additional breast cancer scRNA-Seq metadata (31, 32) (Supplemental Figure 2, D and E), with the highest average signature expression in lipid-associated macrophages (LAMs) (Figure 2D).