ACVRL1 and neoplasm: Nonetheless, in the context of the increasing use of neoadjuvant IT in TNBC patients, it is worth mentioning that we observed a trend toward fewer malignant foci to the lungs in any treatment group that included neoadjuvant ALK1-Fc in our mouse models (Supplemental Figure 1), suggesting that the molecular cues in the metastatic colonization and growth are only partially overlapping with those of the primary tumor mass.