A mitochondrial complex I inhibitor rotenone-induced neurotoxicity with reduction of Ndfip1 expression and increases in α-synuclein expression in cultured neuroblastoma cells were prevented by high expression of Ndfip1, suggesting that upregulation of Ndfip1 after rotenone exposure is adaptive or protective response to the toxicity (Liu et al. 2020). The gene discussed is NDFIP1; the disease is neuroblastoma.