Some reports have shown that LCN2 inhibition promotes the development of diet-induced insulin resistance (Guo et al. 2010), while LCN2 administration enhances pancreatic β-cell proliferation increases insulin production and reduces insulin resistance and blood glucose levels in mice with type 2 diabetes (Mosialou et al. 2020). This evidence concerns the gene LCN2 and type 2 diabetes mellitus.