LCN2 can regulate appetite by activating the anorexigenic pathway in the hypothalamus, as has been previously demonstrated (Mosialou et al. 2017; Petropoulou et al. 2020), which in the context of T2D is relevant because alterations in food intake have been related to the development of the disease (Taylor et al. 2021); however, to date, it has been little explored. The gene discussed is LCN2; the disease is type 2 diabetes mellitus.