We further analyzed the top 30 genes exhibiting the most significant differences between the AKI and AKI + P. gingivalis groups, finding a close correlation between inflammatory factors and renal function indicators, such as neutrophilic granule protein (Ngp), Il6, Il1r2, Osm, and Cxcl2 (Fig. S4A), Moreover, the results of qPCR experiments verified those of the transcriptome sequencing (Fig. S4B). Here, IL1R2 is linked to acute kidney injury.