SP140 and Granuloma: We discovered that (i) C3HeB/FeJ mice infected with the latent UgCl223 clinical isolate produce pulmonary granulomas and immune responses distinct from C57Bl/6J and Mycobacterium-infected C3HeB/FeJ mice; (ii) that Sp140-deficiency alone is not sufficient to replicate the C3HeB/FeJ cryptococcal response as was previously shown for Mycobacterium tuberculosis infections; and (iii) latent Cryptococcus-infected C3HeB/FeJ mice exhibit early, intermediate, and late phases of granuloma formation.