ATP8B1 and infection: After 6 h of Fa7/1 Colon26 anaerobic coculture (multiplicity of infection [MOI 10:1), we profiled the expression patterns of Fic1–6 by quantitative RT-PCR (RT-qPCR) relative to Fa7/1 overnight cultures re-grown in infection media and found significant differential gene upregulation by robust mean fold change analysis (RMFC, Fig. 5a); average RMFCs of Fic2, 3 and 6 were relatively higher (1.94–2.20, q = 4.49 × 10−7 ~ 4.27 × 10−6) than those of Fic1, 4, and 5 (1.70–1.78, q = 4.27 × 10−6 ~ 6.12 × 10−3).