Herein, levels of Nrf2 and HO‐1 in lung tissues were significantly enhanced in ALI mice, which were further strikingly boosted by 0.1 and 0.5 μg AnxA1, suggesting that AnxA1 activates the Nrf2/HO‐1 signaling during ALI (Figure 7). This evidence concerns the gene HMOX1 and acute respiratory distress syndrome.