Although PRCC‐TFE3 KI/Hif1α KO showed a reduction in both tumor area and number, cystic tubular dilation was still observed in the tissue, suggesting that Hif1α KO does not completely reverse the pathological changes in the kidneys of PRCC‐TFE3 KI (Figure 4C,G). Here, TFE3 is linked to neoplasm.