To further characterize PRCC‐TFE3 regulation in vivo, we analyzed gene expression profiles from our PRCC‐TFE3–expressing TFE3‐RCC mouse model (Baba et al. 2019; Funasaki et al. 2022) and confirmed that the hypoxia hallmark is enriched in the PRCC‐TFE3–expressing kidneys (Figures 1E and Figure S4). This evidence concerns the gene TFE3 and renal cell carcinoma.