We found that HIF1α and HIF2α are direct transcriptional targets of PRCC‐TFE3 and confirmed their expression in TFE3‐RCC tissues, thereby establishing a clear connection between the TFE3 fusion protein and the hypoxia signaling pathway, which is central to many cancers, including ccRCC (Chappell, Payne, and Rathmell 2019; Wicks and Semenza 2022; Chen et al. 2023). This evidence concerns the gene EPAS1 and cancer.