Likewise, mutations in fumarate hydratase (FH) and succinate dehydrogenase (SDH) subunits, which are associated with hereditary leiomyomatosis and RCC (HLRCC) and hereditary paraganglioma–pheochromocytoma syndrome, respectively, also induce metabolic perturbations and HIF stabilization (Linehan et al. 2019). Here, FH is linked to renal cell carcinoma.