Indeed, BHB concentration decreased in PRCC‐TFE3 KI and PRCC‐TFE3 KI/Hif2α KO kidneys, whereas it was either increased or maintained in PRCC‐TFE3 KI/Hif1α KO and PRCC‐TFE3 KI/Hif1α/Hif2α DKO kidneys (Figure 5F), suggesting that BHB production is inversely correlated with tumor development. This evidence concerns the gene EPAS1 and neoplasm.