To further characterize PRCC‐TFE3 regulation in vivo, we analyzed gene expression profiles from our PRCC‐TFE3–expressing TFE3‐RCC mouse model (Baba et al. 2019; Funasaki et al. 2022) and confirmed that the hypoxia hallmark is enriched in the PRCC‐TFE3–expressing kidneys (Figures 1E and Figure S4). Here, PRCC is linked to renal cell carcinoma.