Heat shock proteins also interact with the hypoxia‐associated transcription factor hypoxia‐inducible factor 1‐alpha (HIF1A),23 the increased expression of which along with another hypoxia‐associated DEG and transcription factor forkhead box O3 (FOXO3) may arise from pathology such as reduced cerebral blood flow in AD and HD patients.25, 26. The gene discussed is FOXO3; the disease is Huntington disease.