Notably, HSP90AA1, HSP90AB1, and HSP1B all interact with the neuroinflammatory‐associated transcription factor signal transducer and activator of transcription 3 (STAT3), the inhibition of which in ECs has been shown previously to attenuate amyloid pathology and cognitive deficits in an AD mouse model.24 Here, STAT3 is linked to Cognitive impairment.