IL6 and infection: Our system also elicited a distinct inflammatory response, aligning with previous in vivo findings on the cytokine release profile during STm infection.[56, 57] Previous work has shown the capacity of human intestinal epithelial cells to secrete IL‐8 but not IL‐6 and IL‐1.[58] Therefore, we could assume that co‐culture with MDMs primed the secretion of IL‐1, IL‐6, and IL‐10 as a response to the pathogen.