PNPLA3 and obesity due to melanocortin 4 receptor deficiency: Apart from the known role of insulin resistance and obesity, genome-wide studies demonstrated a substantial correlation between various forms of genes within patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 along with transmembrane 6 superfamily 2 human gene (TM6SF2) rs 58542926 with liver fat [5].