Normal levels of FSH and LH are crucial for the regulation of the reproductive cycle as an imbalance in these levels can lead to many complications of ovarian diseases like ovarian tumors, PCOS, and ovarian cancers, as described by McNamara (2021) that LH/FSH ratio higher than 2 indicates PCOS or other ovarian disease. This evidence concerns the gene PLOD1 and ovarian carcinoma.